From State Route 202 WEST take the 44th Street exit. Turn left (south) onto 44th Street. Travel south to Washington Street (approximately 1.5 miles). Take a left (east) on Washington Street. The museum is on the right (south) side of the road.

Pueblo Grande Museum supports Valley Metro Light Rail. Pueblo Grande Museum can be accessed from right-turn-in and right-turn-out access only along Washington street. Westbound traffic along Washington Street is allowed U-turns at 44th Street

From State Route 143 NORTH take the Washington exit east to 48th street. Make a left (north) on 48th Street to Van Buren. Make a left (west) onto Van Buren to 44th street. Make a left (south) onto 44th Street to Washington street. Make a final left (east) onto Washington. The museum is the first right hand turn-in.